![]() Citation6 Medicine has expanded its taxonomies from descriptions of experienced and manifest disease to indicators (eg, biomarkers), risk factors (eg, hypertension), Citation7 social phenomena (eg, behaviour), aesthetic phenomena (eg, look), and many non-harmful conditions. While we can detect many more phenomena than ever before, we lack knowledge of whether they represent or predict anything that is clinically relevant, such as pain, dysfunction, and suffering. Not only do we lack curative measures for all diagnoses, but the many diagnostic technologies also come with errors, Citation5 and we come to diagnose when it does not help people. However, our diagnostic capacities by far outrun our abilities to help. By differentiating existing diagnoses in more precise and actionable entities, more people can be helped - better and earlier than ever before. ![]() Part of this expansion stems from an ample increase in knowledge about bodily, behavioural, and mental mechanisms. ![]()
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